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The antitumor effect of magnetic nanodisks and DNA aptamer conjugates |
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| Authors: | P D Kim S S Zamay T N Zamay V S Prokopenko O S Kolovskaya G S Zamay V Ya Princ V A Seleznev A I Komonov E A Spivak R Yu Rudenko A V Dubinina A V Komarov V V Denisenko M A Komarova A E Sokolov A A Narodov V P Zjivaev A S Zamay |
| Abstract: | Here we describe a method of forming large arrays (up to 109 pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells. |
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