Experimental study on interactions between selenium and tin in mice |
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Authors: | Momoko Chiba Nobuko Kamiya Masakazu Kikuchi |
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Institution: | 1. Department of Hygiene, Juntendo University School of Medicine, Hongo, 113, Tokyo, Japan
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Abstract: | The organ distributions of tin and selenium, and their excretion into urine and feces, were determined in mice. There were
four groups; (A) control, (B) Sn (5 μmol/kg/d) ip injection, (C) Se (5 μmol/kg/d) sc injection, and (D) Sn plus Se (5 μmol/kg/d,
each). Animals received injections once a day for 12 consecutive days. The results were the following (1) Simultaneous injection
of Sn and Se enhanced accumulation of both elements in the body, i.e., in group B, 14.1% of the total injected amount of Sn
was excreted into urine and feces; in group C, 46.2% of total injected Se was excreted into urine and feces; in group D, 10.9%
of total Sn and 37.5% of total Se were found in excreta. (2) Large amounts of Sn were found in bone, liver, spleen, and kidney
in group B. When Se was administered jointly with Sn, the concentrations of Sn in bone and liver were suppressed, whereas
those in spleen and pancreas were increased. (3) The effects of Se-injections at this dose on concentrations of Se in organs
were small. (4) In plasma, chemical reduction of selenite by stannous chloride was not observed. |
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Keywords: | Index Entries" target="_blank">Index Entries Tin selenium δ -aminolevulinic acid dehydratase (ALAD) accumulation excretion |
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