Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation. |
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Authors: | T Tasara M O Hottiger U Hübscher |
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Institution: | Institute of Veterinary Biochemistry, University of Zürich-Irchel, Zürich, Switzerland. |
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Abstract: | Identification and characterization of protein-protein interactions between the host cell and parasites both enhance our understanding of basic cell biology and provide insights into central processes of parasite life cycles. Research on HIV-1 has broadened our knowledge of the various molecular events involved. However, our understanding of how this virus interacts with the host cell at the level of protein-protein interaction is still limited. Through these interactions the virus is able to recruit certain cellular metabolic pathways for its replication. Here we summarize our current knowledge of protein-protein interactions between HIV-1 and host cell factors during viral replication. |
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