Population distribution in North and Central America of PGM1 and Gc subtypes as determined by isoelectric focusing (IEF)

Gc subtypes of 20 North and Central American populations and PCM₁ subtypes in 11 populations were analyzed to identify interpopulation variation of the respective gene frequencies for common alleles. A total of 23,304 phenotypings were done. Absolute heterozygosity levels (D) generally increased twofold when phenotyping by isoelectric focusing was compared with conventional electrophoresis. Graphic representation of the Gc subtypes and multivariate analysis to identify genetic affinities of the populations under study reveal genetic clusters consistent with major historical and geographical groupings of man.