Expression of basic fibroblast growth factor in human gastric carcinomas |
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| Authors: | Hirotoshi Tanimoto Kazuhiro Yoshida Hiroshi Yokozaki Wataru Yasui Hirofumi Nakayama Hisao Ito Koso Ohama Eiichi Tahara |
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| Institution: | 1. First Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan
2. Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan
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| Abstract: | The expression of mRNA for the basic fibroblast growth factor (FGF) gene was examined in seven human gastric carcinoma cell
lines and in tissue from 29 gastric carcinomas together with the adjacent normal mucosa. Among the seven gastric carcinoma
cell lines, the MKN45 cell line expressed mRNA for the basic FGF gene. Basic FGF protein production was confirmed by flow
cytometric analysis and immunohistochemistry. Among the surgical specimens, 16 (55%) of 29 gastric carcinomas showed higher
levels of basic FGF mRNA than the normal mucosa. Interestingly, in scirr-hous gastric carcinomas characterized by their fibrous
stroma and rapid growth, 9 (69%) of 13, samples examined revealed higher levels of basic FGF mRNA than normal mucosa, whereas
only 3 (33%) of the 9 well differentiated adenocarcinomas studied produced similar results. Immunohistochemically, basic FGF
protein was localized in tumor cells. These results suggest that basic FGF produced by tumor cells may play an important role
in producing fibrosis and angiogenesis in gastric carcinomas. |
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| Keywords: | bFGF Human stomach Scirrhous carcinoma |
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