Fluorometrical Analysis of Guanidino Compounds in Human Cerebrospinal Fluid |
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| Authors: | Akitane Mori Yoko Watanabe Noboru Fujimoto |
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| Affiliation: | Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, Japan |
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| Abstract: | Abstract: Guanidino compounds in CSF of 57 human subjects were determined fluorometrically after reaction with phenanthrenequinone in alkali solution, using HPLC. Creatinine (65.2 ± 13.4 nmol/ml), arginine (24.7 ± 6.4 nmol/ml), and homoarginine (0.7 ± 0.3 nmol/ml) were found in all subjects. Trace amounts of guanidinosuccinic acid and guanidinoacetic acid were detected in some of the subjects. Brain guanidino compounds, taurocyamine, N -acetylarginine, and methylguanidine were not detected in CSF. |
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| Keywords: | Guanidino compounds Human cerebrospinal fluid |
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