New lipoxygenase-inhibiting constituents from Calligonum polygonoides |
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| Authors: | Yawer Mirza Arfan Ahmed Ejaz Malik Abdul Ashraf Muhammad Rasool Muhammad Azam Afza Nighat |
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| Institution: | International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. |
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| Abstract: | Calligonolides A (1) and B (2), two new butanolides, and a new steroidal ester, 3, have been isolated from the whole plant of Calligonum polygonoides, together with four known compounds, tetracosan-4-olide, beta-sitosterol and its glucoside, and ursolic acid. Their structures were elucidated by spectroscopic and mass-spectrometric studies. Compounds 1-3 showed moderate inhibitory potential against lipoxygenase from soybean. |
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| Keywords: | Calligonum polygonoides Calligonolides A and B Inhibitors Steroidal esters Butanolides Lipoxygenase inhibitors |
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