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Inhibition of Acetylcholinesterases from Aphelenchus avenae by Carbofuran and Fenamiphos
Authors:D J Pree  J L Townshend  K J Cole
Abstract:Exposure to carbofuran and fenamiphos for 72 hours reduced the numbers of active Aphelenchus avenae in aqueous suspension by > 75%. When nematicides were removed, many A. avenae exposed to carbofuran resumed normal movement but A. avenae treated with fenamiphos did not recover. Acetylcholinesterase (AChE) activity was suppressed by > 95% in nematodes treated with carbofuran or fenamiphos. However, 48 hours after treated nematodes had been placed in water, AChE activity in carbofuran treated populations was 98% of the levels in control nematodes. Nematodes that had been treated with fenamiphos showed only slight AChE recovery. The antidotes, atropine sulfate and 2-PAM, were largely ineffective in counteracting the toxic effects of the nematicides.
Keywords:acetylcholinesterase  antidote  Aphelenchus avenae  carbofuran  fenamiphos  nematicide
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