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Immunoglobulin-positive cells from the gland of harder and bone marrow of the chicken
Authors:B Glick  D S Rao  R Stinson  F C McDuffie
Affiliation:1. Poultry Science Department, Mississippi Agricultural and Forestry Experimental Station, Mississippi State University, Mississippi State, Mississippi 39762, USA;2. Mayo Foundation, Departments of Medicine and Immunology, Rochester, Minnesota 55901 USA
Abstract:Cells were collected from the gland of Harder (GH) and bone marrow (BM) of 14-, 21- and 32-week-old birds and were incubated with an 125I-labeled rabbit anti-chicken Ig (IgG and IgM) serum. At 14 weeks of age the percentage of Ig+ small lymphocytes (SL) in the GH and BM was similar. However, by 21 weeks of age Ig+ SL in BM had increased to approximately 19% of total lymphocytes while the Ig+ SL in the GH represented less than 1.7% of the lymphocyte pool. A marked drop in the number of Ig+ SL in BM occurred by 32 weeks of age. These data suggest that either the BM may be dependent on the bursa for maintenance of its Ig+ SL or it is unable to produce in situ or maintain Ig+ SL with age. In the GH the predominant cell was the plasma cell (PC). Labeled PC (> 20 grains) exceeded 80% of the total PC pool in the GH. These data contrast with the apparent deficiency of Ig receptors on murine PC. The maintenance of a large number of PC in the GH without the presence of Ig+ SL illustrates the uniqueness of this gland.
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