Malaria parasites: Randomly interbreeding or 'clonal' populations?

Malaria parasites: Randomly interbreeding or ‘clonal’ populations?

The 'clonality' hypothesis proposed by Michel Tibayrenc and his colleagues(1) has stimulated a long-overdue debate on the genetic structure of populations of protozoan parasites. A critical aspect of the hypothesis is the role of a sexual phase in the life cycle of these organisms. In the malaria parasite, Plasmodium, the existence of a sexual phase is unquestioned and is, indeed, a compulsory part of the cycle in the mosquito host. For this parasite, therefore, the principal question to be addressed, here by David Walliker, is whether populations of this parasite in nature are in a state of random mating (panmixia) or whether they comprise a limited number of clones which only occasionally undergo crossmating.