A comparison of viable counts and adenine nucleotide analysis to determine the effect of antimicrobial agents on dental plaque |
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| Authors: | Stanley A Robrish Claes-Göran Emilson Christopher W Kemp Doreen Eberlein William H Bowen |
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| Institution: | (1) Etiology Section of the National Caries Program, National Institutes of Health, Park-5 Building, Room 415, 20205 Bethesda, Maryland, USA;(2) Faculty of Odontology, University of Gothenburg, Gothenburg, Sweden |
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| Abstract: | The effects of three antimicrobial agents on smooth surface dental plaque in monkeys were assessed using a plaque index, bacterial viable count, and adenine nucleotide analysis. The effects of the agents were revealed equally well when, viability was assayed by extractable adenosine triphosphate (ATP) or conventional viable cell counts. A persistent effect of one of the agents was revealed by both viable count and extractable ATP. These interpretations were supported by calculations of adenylate energy charge from the adenine nucleotide content of the smooth surface dental plaque samples. |
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