Association and impact of <Emphasis Type="Italic">XPG Asp</Emphasis> 1104 <Emphasis Type="Italic">His</Emphasis> gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals |
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Authors: | Ranbir Chander Sobti Nega Berhane Salih Abedule Mehedi Rupinder Kler Seyed Ali Hosseini Vijish Kuttiat Ajay Wanchu |
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Institution: | (1) Department of Biotechnology, Panjab University, Chandigarh, 160014, India;(2) Department of Internal Medicine Postgraduate, Institute of Medical Education and Research, Chandigarh, India |
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Abstract: | Various efforts made to stop the deadly epidemic of HIV since its discovery in 1983 remain unsuccessful and this virus still
continues to claim the lives of millions of individuals every year. The viral effect in the cell is complicated and the overall
disease outcome is the result of interaction between a few viral proteins and complex host immune response. Because it has
been reported that XPG (Xeroderma pigementesum group G) gene does play a role in reducing UV induced apoptosis and participate in Nucleotide Excision
Repair (NER) process of DNA damage, it was hypothesized that polymorphism in this gene may have a role in HIV 1 disease progression
to AIDS. The aim of the present study, therefore, was to find out the association between XPG gene polymorphism and its effect on the rate of HIV 1 disease progression to AIDS. 300 HIV seropositive cases and an equal
number of age and sex matched controls were recruited for the study from north Indian population. The PCR-RFLP method was
utilized to genotype 600 study subject for the XPG Asp
1104
His gene polymorphism. There was significant difference in the frequency of the His/His variant genotype (OR 1.95, 95% CI = 1.93–3.63, P = 0.04) between cases and controls indicating a probable role of this gene in host viral interactions. |
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