Neuroprotective effect of choline succinate in rats with experimental chronic cerebral ischemia evaluated by cognitive ability tests |
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| Authors: | N A Pomytkin Z I Storozheva N A Semenova A T Proshin V V Sherstnev S D Varfolomeev |
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| Institution: | (1) Scientific and Technical Center “Fine Technologies”, Leningradskoye sh. 55A, Moscow, 125195, Russia;(2) P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, ul. Mokhovaya 14/11, Moscow, 125009, Russia;(3) Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia;(4) Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia |
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| Abstract: | The neuroprotective effect of choline succinate was studied in rats with chronic cerebral ischemia induced by ligation of both common carotid arteries. Two approaches were used to evaluate the neuroprotective effect: cognitive ability tests (passive avoidance test and Morris water maze test) and determination of the brain content of N-acetylaspartate, a marker of functional neurons, by 1H NMR spectroscopy in vivo. Choline succinate administration significantly improved memory and learning in ischemic rats and prevented the ischemia-induced decrease in the cerebral level of N-acetylaspartate. Thus, choline succinate demonstrated a neuroprotective effect in conditions of ischemic brain injury. |
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