Prostaglandins V (1). Synthesis and pharmacology of (±)-11-deoxy-10-hydroxyprostaglandin E1 methyl ester |
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| Authors: | M.P.L. Caton G. Darnbrough D.J. Hambling R. Jordan T. Parker |
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| Affiliation: | The Research Laboratories, May and Baker Ltd., Dagenham, Essex, RM10 7XS, England |
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| Abstract: | (±)-11-Deoxy-10-hydroxy-PGE1 methyl ester (Va) has been synthesised conjugate addition of the cuprate (III) to the 5-tetrahydropyranyloxycyclopentenone (IId).Va was found to be 0.1 times as active as PGE1 as a uterine stimulant in the anaesthetized pregnant rat, 0.25 times as active as PGE1 in causing vasodepression in the anaesthetized cat, and approximately equiactive to PGE1 in inducing bronchoconstriction. |
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