Relationships between blood platelet and erythrocyte formation |
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Authors: | George W. Cooper Barbara Cooper |
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Affiliation: | The City College of the City University of New York, New York, N.Y. 10031, USA |
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Abstract: | The rate of thrombopoiesis was measured by platelet incorporation of 35S-sulfate in mice having markedly stimulated or suppressed erythropoiesis, and compared to controls. Twenty-four hr exposure to 0.4 atm in a low pressure chamber caused increased platelet incorporation of 35S, while exposure for 2 to 5 days caused reductions in both 35S uptake and platelet counts at time of sacrifice. These values were progressively reduced with the longer periods of hypoxia. Two units of human urinary erythropoietin (ESF) were injected twice daily for 1 to 5 days and also caused reduced platelet 35S uptake in mice given the ESF for 2, 4, or 5 days. Mice rendered polycythemic by hypertransfusion or previous exposure to low barometric pressure had increased platelet 35S uptake and increased platelet counts. One possible explanation is that the severe hypoxia or the administration of ESF strongly stimulated erythropoiesis, but might have inhibited thrombopoiesis by depleting megakaryocyte precursors in the bone marrow. |
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