Enhanced erythroid burst formation in mice after testosterone treatment |
| |
Authors: | Cesare Peschle Maria Cristina Magli Clemente Cillo Federico Lettieri Francesco Pizzella Arturo Genovese Andrea Soricelli |
| |
Institution: | Institute of Medical Pathology and International Center for Hematology and Oncology, II Faculty of Medicine and Surgery, University of Naples, Naples, Italy |
| |
Abstract: | A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36–49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|