Variation in the NRAMP1 gene does not affect susceptibility or protection in human brucellosis |
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| Authors: | Bravo Maria José Colmenero Juan de Dios Martín Javier Alonso Antonio Caballero González Abelardo |
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| Affiliation: | 1. Immunology Service, Carlos Haya University Hospital, Malaga, Spain;2. Internal Medicine Service, Carlos Haya University Hospital, Malaga, Spain;3. Parasitology and Biomedicine, Lopez-Neyra Institute, Granada, Spain;1. Promega Corporation, Fitchburg, WI 53711, USA;2. Promega Biosciences, San Luis Obispo, CA 93401, USA;1. ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, India;2. College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India;3. Replicon Research Center, Masters in Genetics, School of Agrarian and Biological Sciences, Pontifical Catholic University of Goiás, Goiânia, Brazil;4. Graduate Program in Animal Sciences, School of Veterinary Medicine and Animal Science, Federal University of Goiás, Goiânia, Brazil;5. Postgraduate Program in Biotechnology and Biodiversity, Federal University of Goiás, Goiânia, Brazil;1. Indian Council of Agricultural Research- National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bangalore, 560 064, India;2. ICAR-National Research Centre on Meat, Chengicherla, Hyderabad, 500092, India;1. Division of Insect Sciences, National Institute of Agrobiological Sciences, 1-2, Owashi, Tsukuba, Ibaraki 305-8634, Japan;2. Division of Animal Sciences, National Institute of Agrobiological Sciences, 2, Ikenodai, Tsukuba, Ibaraki 305-8602, Japan;1. Department of Biochemistry and Nutrition, Faculty of Medicine – University of Gezira, Sudan;2. Department of Molecular Biology – National Cancer Institute – University of Gezira, Sudan;3. Health Technology and Informatics Department – The Hong Kong Polytechnic University, Hong Kong |
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| Abstract: | ![]()
Genetic susceptibility to human brucellosis has so far been localized to variants of genes, which participate in the specific response and the innate immune response. The Nramp1 gene, which participates in the innate response, is related to susceptibility and protection in bovine brucellosis. We examined the polymorphism of the human NRAMP1 gene in 65 patients with brucellosis and 89 healthy controls and found no significant differences in the alleles studied. Thus, variants of the NRAMP1 gene do not appear to affect susceptibility or protection in human brucellosis. |
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