| 纺锤体组装检控点 |
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| 引用本文： | 欧赛英,欧阳高亮,鲍仕登.纺锤体组装检控点[J].细胞生物学杂志,2006,28(2):145-148. |
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| 作者姓名： | 欧赛英 欧阳高亮 鲍仕登 |
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| 作者单位： | 厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室 厦门361005 |
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| 摘 要： | 细胞有丝分裂过程中,纺锤体组装检控点监控着染色体在赤道板的队列和向纺锤体两极的分离,确保动粒-微管的黏附和有丝分裂器的完整,使所有的染色体都置于赤道板并双极定向后才进入后期,保证遗传物质均等地分配给两个子代细胞。纺锤体组装检控点缺陷将导致非整倍体的出现,并与一些肿瘤的发生密切相关。现就近年来纺锤体组装检控点蛋白以及纺锤体组装检控点功能缺陷与肿瘤的关系方面的研究进展作一简要综述。
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| 关 键 词： | 细胞周期检控点 纺锤体组装检控点 动粒 肿瘤 |
| 收稿时间： | 2005-07-20 |
| 修稿时间： | 2005-11-22 |
Spindle Assembly Checkpoint |
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| Sai-Ying Ou,Gao-Liang Ouyang,Shi-Deng Bao.Spindle Assembly Checkpoint[J].Chinese Journal of Cell Biology,2006,28(2):145-148. |
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| Authors: | Sai-Ying Ou Gao-Liang Ouyang Shi-Deng Bao |
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| Institution: | The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China |
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| Abstract: | Chromosomes aligned to the metaphase plate and segregated to the mitotic spindle are regulatedby the spindle assembly checkpoint. This surveillance mechanism monitors kinetochore-microtubule attachmentand the integrity of the mitotic apparatus, and is able to delay the metaphase-anaphase transition until all chromo-somes are properly aligned at the metaphase plate and established a bipolar orientation, ensuring equal segregation ofgenomic material among daughter cells. Functional defects in spindle assembly checkpoint can generate grossaneuploidy and are associated with tumorigenesis. In this review, we will focus on the molecular components ofspindle assembly checkpoint pathway and the relationship between the function defects of this checkpoint andtumorigenesis. |
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| Keywords: | cell cycle checkpoint spindle assembly checkpoint kinetochore tumor |
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