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Antinociceptive activity of the volatile oils of Hyptis pectinata L. Poit. (Lamiaceae) genotypes |
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| Authors: | M.F. Arrigoni-Blank A.R. Antoniolli L.C. Caetano D.A. Campos A.F. Blank P.B. Alves |
| Affiliation: | aNúcleo de Ciências Biológicas, Campus Prof. Alberto Carvalho, Universidade Federal de Sergipe, Itabaiana, Av. Vereador Olímpio Grande s/n, 49500-000 Sergipe, Brazil bDepartamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil cDepartamento de Química, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil dDepartamento de Engenharia Agronômica, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil eDepartamento de Química, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil |
| Abstract: | Hyptis pectinata L. Poit (Lamiaceae) is known popularly in Brazil as “sambacaita” or “canudinho” and is used in the treatment of inflammations, bacterial infections and ache. The antinociceptive activity of the volatile oils of six genotypes, at doses of 100, 200 and 400 mg/kg body wt., were investigated using abdominal writhe models induced by acetic acid and hot plate tests. The volatile oils of all the genotypes are composed mainly of sesquiterpenoids. All the genotypes showed antinociceptive effects in both models used; the SAM002 genotype showed the major inhibitory effect at dose of 100 mg/kg body wt. These results suggest that the volatile oil of H. pectinata has peripheral (writhe reduction) and central (time delay of thermal reaction) effects. These observations indicate that H. pectinata may be useful as an analgesic drug. |
| Keywords: | Hyptis pectinata Acetic-acid-induced abdominal constrictions Hot-plate test Acute toxicity Native medicinal plant |
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