| miRNAs与衰老相关信号通路的研究进展 |
| |
| 引用本文： | 荆霞,熊兴东,刘新光.miRNAs与衰老相关信号通路的研究进展[J].中国生物化学与分子生物学报,2013,29(5):412-418. |
| |
| 作者姓名： | 荆霞 熊兴东 刘新光 |
| |
| 作者单位： | 广东医学院衰老研究所;广东省医学分子诊断重点实验室;广东医学院生物化学与分子生物学研究所 |
| |
| 基金项目： | 国家自然科学基金(No.30672205,30871440,30971620,81000143,81170327);广东省自然科学基金(No.S2012010008219,9252402301000002,S2011010002922,8452402301001450);东莞市科技计划重点项目(No.2011105102007);广东省医学科研基金项目(No.A2011431);广东医学院科技创新基金(No.STIF201102)~~ |
| |
| 摘 要： | miRNAs是一类负调控基因表达的内源性非编码小分子RNA，在细胞衰老过程中发挥重要作用. 细胞衰老是指可增殖细胞在各种应激下出现细胞周期阻滞，并且丧失增殖能力，进入一种不可逆的、相对稳定的状态. p53、p21、p16、SIRT1、胰岛素/IGF-1及mTOR等蛋白是衰老相关信号通路中的重要分子，参与细胞衰老过程. 研究表明，miRNAs可以通过调控这些衰老相关蛋白所在的信号通路，促进或延缓细胞衰老. 本文综述细胞衰老相关的miRNAs，以及它们对衰老相关信号通路的影响，为深化认识衰老和衰老相关疾病的分子机制奠定基础.
|
| 关 键 词： | miRNAs 信号通路 细胞衰老 |
| 收稿时间： | 2012-12-18 |
The Role of miRNAs in Aging-related Signaling Pathways |
| |
| JING Xia,XIONG Xing-Dong,LIU Xin-Guang.The Role of miRNAs in Aging-related Signaling Pathways[J].Chinese Journal of Biochemistry and Molecular Biology,2013,29(5):412-418. |
| |
| Authors: | JING Xia XIONG Xing-Dong LIU Xin-Guang |
| |
| Institution: | 1),2),3)*(1)Institute of Aging Research,Guangdong Medical College,Dongguan 523808,Guangdong,China; 2)Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Dongguan 523808,Guangdong,China; 3)Institute of Biochemistry & Molecular Biology,Guangdong Medical College,Zhanjiang 524023,Guangdong,China) |
| |
| Abstract: | MicroRNAs (miRNAs) are small endogenous noncoding RNA molecules that are able to repress gene expression, and are known to play essential roles in the controlling of cellular senescence. Cellular senescence is represented by the irreversible proliferation arrest in response to various types of stress. The aging related signaling pathways involving p53, p21, p16, SIRT1, insulin/IGF-1 and mTOR have been shown to be important in recent reports, where the miRNAs could either promote or delay cellular senescence through regulating the aging related signaling proteins. Here we reviewed the reported aging related miRNAs with their roles on the signaling pathways in cellular senescence. |
| |
| Keywords: | miRNAs signaling pathways cellular senescence |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息 |
| 点击此处可从《中国生物化学与分子生物学报》下载免费的PDF全文 |
|
