Time Course of Changes in Immunoreactivities of GABA Degradation Enzymes in the Hippocampal CA1 Region after Adrenalectomy in Gerbils |
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Authors: | In Koo Hwang Ki-Yeon Yoo Hua Li Jung Hoon Choi Choong Hyun Lee Dae Won Chung In Se Lee Dae Won Kim Soo Young Choi Moo-Ho Won |
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Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(3) Department of Biomedical Sciences and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, 200-702, South Korea |
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Abstract: | Adrenalectomy (ADX) has been useful for a good in vivo model for apoptosis in the hippocampus by the absence of corticosteroids
following ADX. In some neurodegenerative diseases, GABAergic neurons are more resistant to neuronal damage as compared with
glutamatergic neurons. In the present study, we observed chronological changes in three GABA degradation enzymes, e.g., GABA
transaminase (GABA-T), succinic semialdehyde dehydrogenase (SSADH) and succinic semialdehyde reductase (SSAR) immunoreactivity
and protein levels in the gerbil hippocampal CA1 region after ADX. Changes in their immunoreactivities were distinct in the
stratum pyramidale of the CA1 region. GABA-T immunoreactivity and protein level were significantly increased in the CA1 region
3 h after ADX, in contrast, SSAR and SSADH immunoreactivity and protein level were increased 12 h and 3–12 h, respectively,
after ADX. These results suggest that the increases of GABA-T, SSADH and SSAR immunoreactivity and protein levels in the hippocampal
CA1 region in ADX gerbils may be associated with the control of GABA levels in this region. |
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Keywords: | Adrenalectomy GABA GABA transaminase Succinic semialdehyde dehydrogenase Succinic semialdehyde reductase Hippocampal CA1 region Gerbil |
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