| 丙型肝炎病毒细胞和动物模型的研究进展 |
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| 引用本文： | 张立营,高博,冯玉奎.丙型肝炎病毒细胞和动物模型的研究进展[J].生物技术通讯,2011,22(2):277-280. |
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| 作者姓名： | 张立营 高博 冯玉奎 |
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| 作者单位： | 1. 济南军区青岛第二疗养院,检验科,山东,青岛,266071
2. 军事医学科学院,野战输血研究所输血安全实验室,北京,100850 |
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| 基金项目： | 青岛市公共领域科技支撑计划(09-1-1-28-nsh) |
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| 摘 要： | 丙型肝炎病毒(HCV)是造成慢性肝炎、肝硬化及肝癌的重要病因之一,目前全世界约1.7亿人感染HCV.HCV的自然宿主范围很窄,由于缺少有效的HCV细胞培养系统和小动物模型,人们对其生活周期、作用机制等仍不是很清楚,从而严重阻碍了HCV疫苗及治疗药物的开发与研制.我们简要综述了近几年在HCV细胞和动物模型方面的进展,同时...
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| 关 键 词： | 丙型肝炎病毒 细胞模型 动物模型 |
Progress in Establishment of Hepatitis C Virus Cell and Animal Models |
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| ZHANG Li-Ying,GAO Bo,FENG Yu-Kui.Progress in Establishment of Hepatitis C Virus Cell and Animal Models[J].Letters in Biotechnology,2011,22(2):277-280. |
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| Authors: | ZHANG Li-Ying GAO Bo FENG Yu-Kui |
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| Institution: | ZHANG Li-Ying1,GAO Bo2,FENG Yu-Kui1 1.The 2nd Sanatorium of Ji'nan Military Command,Qingdao 266071,2.Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing 100850,China |
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| Abstract: | Hepatitis C virus(HCV) is a major cause of chronic liver disease,such as chronic hepatitis,hepatic cirrhosis,hepatocelhlar carcinoma,with over 170 million persistently infected individuals worldwide.Lacking of cell culture system for HCV and proper study models due to restrictive host range the HCV has,which has brought difficulties in the study of the mechanism of viral infection,life cycle and pathogenic mechanism of HCV and also block the development of efficient vaccine and new drugs for hepatitis C.Her... |
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| Keywords: | hepatitis C virus cell models animal models |
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