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Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts |
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| Authors: | Prosser H C G Leprince J Vaudry H Richards A M Forster M E Pemberton C J |
| Affiliation: | aSchool of Biological Sciences, University of Canterbury, Christchurch, New Zealand bChristchurch Cardioendocrine Research Group, Christchurch School of Medicine, University of Otago, New Zealand cINSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France |
| Abstract: | Urotensin II (UII) was first discovered in the urophyses of goby fish and later identified in mammals, while urotensin II-related peptide (URP) was recently isolated from rat brain. We studied the effects of UII on isolated heart preparations of Chinook salmon and Sprague–Dawley rats. Native rat UII caused potent and sustained, dose-dependent dilation of the coronary arteries in the rat, whereas non-native UII (human and trout UII) showed attenuated vasodilation. Rat URP dilated rat coronary arteries, with 10-fold less potency compared with rUII. In salmon, native trout UII caused sustained dilation of the coronary arteries, while rat UII and URP caused significant constriction. Nω-nitro-l-arginine methyl (l-NAME) and indomethacin significantly attenuated the URP and rat UII-induced vasodilation in the rat heart. We conclude that UII is a coronary vasodilator, an action that is species form specific. We also provide the first evidence for cardiac actions of URP, possibly via mechanisms common with UII. |
| Keywords: | Urotensin II URP Isolated rat heart Salmon coronary arteries Vasodilation |
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