C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells. |
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Authors: | M Furuya M Yoshida Y Hayashi N Ohnuma N Minamino K Kangawa H Matsuo |
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Institution: | Suntory Institute for Biomedical Research, Shimamoto, Osaka, Japan. |
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Abstract: | C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than alpha-human atrial natriuretic peptide (alpha-hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of VSMC was also suppressed by CNP more potently than alpha-hANP, while the peptide was less active for cGMP augmentation and for vasorelaxation than alpha-hANP in isolated rat aorta. These results suggest that CNP may be a growth regulating factor of VSMC rather than a vasodilator. |
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