Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products |
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| Authors: | Mizuno Haruo Ohro Yoichiro Sugiyama Yukari Ito Tetsuya Hasegawa Tomonobu Homma Keiko Ueshiba Hajime Ono Makoto Togari Hajime |
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| Affiliation: | Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. hamizuno@med.nagoya-cu.ac.jp |
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| Abstract: | OBJECTIVE: To clarify the pathogenesis of transient hyper-17alpha-hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17alpha-hydroxyprogesterone (17-OHP) until 2 months of age. METHODS: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. RESULT: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. CONCLUSION: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life. |
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