降纤酶治疗急性脑梗死疗效双盲对照研究

目的 观察降纤酶治疗急性脑梗死的近期疗效及进纤维蛋白原的降解作用。方法 ３７例急性脑梗死患者，采用随机、双盲、安慰剂对照试验方法，随机分为两组（治疗组１８例，其中除误诊１例；安慰剂组１９例）。比较治疗前与治疗第１４天神经功能缺损评分、出院及第１２周随访Ｂａｒｔｈｅｌ指数、两组治疗前及治疗第２、４、６天血纤维蛋白原变化情况。结果 治疗组及安慰剂组治疗后第１４天神经功能改装、出院及第１２周随访Ｂａｒｔ

Double Blind Comparesion of Therapeutic Effect of Defibrase on Acute Cerebral Infarction

Objective To observe the therapeutic effect of defibrase on acute cerebral infarction and its degradation of fribrinogen Methods 37 case of acute cerebral infarction were divided into test group of 18(one them was excluded later due to misdiagnosis),and control group of 19 with double blind methodThe control group was made between the two groups before treatment and the 14th day after the treatmentThe variations of blood fribrinogen of the two groups were observed before the admission to hospital and the 2nd,4th and 6th day after treatmentBarrthel indexes were recorded in the 12th week after they were discharged from hospital Results Both groups showed improvement in neuro function 14 days after receiving treatment and Barrthel indexes also improved in the 12th week of followups without statistical variation(P=0242,P=0635,P=0870)There were differences in fribrinogen reduction in the two groups in the observation on the 2nd,4th and 6th day after treatment(P=0043,P=0001,P=0870)The death rate in the test group was 17:2 while the control group 19:1(P=02) Conclusion Defribrinolysin proves safe clinically and has the effect of fribrinogen reduction and can be used as antithrombusHowever,whether little difference between the two groups in therapeutic effect is rel ated to the dosage needs further study