EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma |
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Authors: | Li Zijian Chen Xue Li Lili Liu Sufang Yang Lifang Ma Xiaoqian Tang Min Bode Ann M Dong Zigang Sun Lunquan Cao Ya |
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Institution: | Key Laboratory of Ministry of Education, Key Laboratory of Ministry of Health, Cancer Research Institute, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China. |
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Abstract: | miRNAs (microRNAs) are a class of non-coding small RNAs. The Epstein-Barr-virus (EBV) encoded miR-BHRF1-1 is barely expressed in most nasopharyngeal carcinoma (NPC) cells with EBV latent infection. Here, we used a strategy of overexpression and inhibition of miR-BHRF1-1 and showed that miR-BHRF1-1 is involved in TPA-induced accumulation of EBV lytic proteins and viral copies in late lytic cycle. The data further suggested that the miR-BHRF1-1-potentiated induction of EBV lytic replication was accompanied by inhibiting p53 expression. Our results demonstrated that the EBV original pathogen miR-BHRF1-1 is involved in the control of EBV late lytic replication by directly targeting the host p53 gene. |
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