Role of iron-ATP complex in lymphocyte proliferation and infiltration |
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Authors: | Leopold J Anghileri Emilio Mayayo Ortal Pierre Thouvenot |
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Institution: | (1) Biophysics Laboratory, Medicine Faculty, Nancy University, France;(2) Pathologic Unit, Medicine Faculty, Rovira i Virgili University, Reus, Spain;(3) Nuclear Medicine Department, Nancy University Medical Center, Nancy, France |
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Abstract: | The roles of sodium-ATP (NaATP) and ferric-ATP complex (FeATP) on the proliferation and infiltration of lymphocytes have been
studied by evaluation of the hypertrophy and histopathologic examination of spleen and liver, as well of the modifications
in the elemental balance of iron, calcium, magnesium, and phosphorus. The results showed that in the implicated biochemical
processes, calcium and magnesium have a principal role. An in vitro study on a cell model has permited one to evaluate the
effects of deferoxamine, a known iron chelator and inhibitor of human lymphocyte proliferation, on FeATP-modified cellular
calcium fluxes. These findings showing a reduced 45Ca2+ uptake in the presence of deferoxamine appear to indicate that in vivo the chelation of blood-borne iron by ATP might play
a key role in proliferation and infiltration of lymphocytes, leading to lymphoma development. |
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Keywords: | Lymphocyte proliferation infiltration lymphomas Ca2+ signal |
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