Synthesis of leucine enkephalin derivatives: structure-function studies |
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Authors: | N S Agarwal V J Hruby R Katz W Klee M Nirenberg |
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Institution: | Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030 USA |
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Abstract: | Nucleoli isolated from livers of rats injected intraperitoneally with one dose of thioacetamide had a five-fold increase in the rate of RNA synthesis when compared with livers of rats treated with saline or CCl4. The stimulation was maximal 24 hours after treatment and decreased to control values 73 hours after treatment. The enhanced level of nucleolar activity was maintained at that level when thioacetamide was injected daily. Along with the increase in the endogenous activity there was a 7-fold increase in the “free” RNA polymerase I activity determined by blocking the bound enzyme with actinomycin D (7). The nucleoli of the thioacetamide-treated rats offer a useful model of modulation of ribosomal gene function. |
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Keywords: | Author to whom reprint request should be sent at the Department of Chemistry University of Arizona Tucson Arizona 85721 |
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