Effect of hyperammonemia on brain amino acids in young and adult ferrets |
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Authors: | D R Deshmukh A Mukhopadhyay A P Sarnaik M Portoles |
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Institution: | (1) Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, 2226 Elliman Building, 48201 Detroit, MI, USA;(2) Present address: Departmento de Enzimologia, Hepatologia Experimental, Hospital La Fe, Centro de Investigacion, Avd de Campanar 21, Valencia, Spain |
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Abstract: | Summary Effects of arginine deficiency and hyperammonemia on the brain concentrations of amino acids and urea cycle enzyme activities in young and adult ferrets were investigated. Only young ferrets developed hyperammonemia and encephalopathy immediately after consuming the arginine-free diet. Brain ornithine and citrulline concentrations in young ferrets fed arginine containing diet were significantly lower than those in adult ferrets. Compared to rats and other animals, young and adult ferrets had lower concentrations of brain glutamic acid and glutamine. Unlike in other species, brain glutamine was not elevated in young, hyperammonemic ferrets. Brain arginase and glutamate dehydrogenase activities were significantly increased in young ferrets fed arginine-free diet. Young ferrets provide a useful animal model for investigating the neurotoxicity of acute hyperammonemia.Abbreviations ACD
Arginine-containing diet
- AFD
Arginine-free diet
This work was presented, in part, at the annual meeting of the Midwest Society for Pediatric Research, Chicago, IL, 1991. |
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Keywords: | Amino acids Arginine Hyperammonemia Ferrets |
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