Genomics of Helper Component Proteinase Reveals Effective Strategy for <Emphasis Type="Italic">Papaya Ringspot Virus</Emphasis> Resistance |
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Authors: | Satendra K Mangrauthia Priyanka Singh Shelly Praveen |
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Institution: | (1) Plant Pathology Section, Directorate of Rice Research, Hyderabad, 30, India;(2) Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi, 12, India; |
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Abstract: | Papaya ringspot virus (PRSV) causes severe economic losses in both cucurbits and papaya throughout the tropics and subtropics. Development of PRSV-resistant
transgenic plants faces a major hurdle in achieving resistance against geographically distinct isolates. One of the major
reasons of failing to achieve the broad-spectrum PRSV resistance is the involvement of silencing suppressor proteins of viral
origin. Here, based on sequence profile of silencing suppressor protein, HcPro, we show that PRSV-HcPro, acts as a suppressor
of RNA silencing through micro RNA binding in a dose- dependent manner. In planta expression of PRSV-HcPro affects developmental biology of plants, suggesting the interference of suppressor protein in micro
RNA-directed regulatory pathways of plants. Besides facilitating the establishment of PRSV, it showed strong positive synergism
with other heterologous viruses as well. This study provides a strategy to develop effective and stable PRSV-resistant transgenic
plants. |
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