Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation |
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| Authors: | Marie-Dominique Ah Kioon Carine Asensio Hang-Korng Ea Benjamin Uzan Martine Cohen-Solal Frédéric Lioté |
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| Affiliation: | 1.INSERM UMR-S 606, Hôpital Lariboisière, Ambroise Paré Street, 75010 Paris, France;2.Paris-Diderot University, Thomas Mann Street, 75013 Paris, France;3.UFR Faculty of Medicine, Square Villemin, 75010 Paris, France |
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| Abstract: | Introduction Rheumatoid arthritis (RA) is characterized by bone and cartilage invasion by fibroblast-like synoviocytes (FLSs). Adrenomedullin, a peptide with anabolic and antiapoptotic properties, is secreted by rheumatoid FLSs. Adrenomedullin also increases the expression of adhesion molecules in endothelial cells and keratinocytes. Here, we investigated whether adrenomedullin mediated FLS adhesion to extracellular matrix (ECM) proteins. |
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