Biosynthesis of Camptotheca acuminata alkaloids |
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| Authors: | Giuma M Sheriha Henry Rapoport |
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| Institution: | Department of Chemistry, University of California, Berkeley, CA 94720, U.S.A. |
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| Abstract: | Tracer feeding experiments with Camptotheca acuminata plants show that 1′-14C]L-tryptophan, Ar-3H4]L-tryptophan, Ar-3H4,1′-14C]tryptophan, 1′-14C]-tryptamine, 2-14C]DL-mevalonate, and 2-14C]geraniol-2-14C]nerol are incorporated into camptothecin. Direct stem injection of the labeled precursors into C. acuminata plants resulted in a substantial increase in the activity of isolated Camptotheca alkaloids as compared to root feeding of the same tracer. |
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| Keywords: | Nyssaceae camptothecin biosynthesis tryptophan tryptamine mevalonate geraniol-nerol |
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