Trace Elements in Fingernails of Healthy Chinese Centenarians |
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Authors: | Yonghua Li Xiaoyan Zou Jinmei Lv Linsheng Yang Hairong Li Wuyi Wang |
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Institution: | (1) Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11A Datun Road, Chaoyang District, Beijing, 100101, China |
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Abstract: | Trace element concentrations in body tissues of healthy centenarians have not been widely analyzed, yet they can be used as
reference data leading to improved assessment of the aging process and monitoring of the micronutrient status of this age
group. The present study sought to assess trace element concentrations and behaviors in the fingernails of healthy Chinese
centenarians. The effects of gender on element concentrations, which also play an important role in determining the lifespan,
were also investigated. Trace elements (Ba, Cd, Co, Cr, Cu, Fe, Li, Mn, Mo, Ni, Pb, Se, Sr, and Zn) in the fingernails of
78 healthy Chinese centenarians were determined by inductively coupled plasma mass spectrometry. The overall reference values
obtained in milligram per kilogram are as follows: Ba, 5.10; Cd, 0.031; Co, 0.101; Cr, 0.82; Cu, 3.71; Fe, 154.35; Li, 0.31;
Mn, 3.09; Mo, 0.040; Ni, 0.95; Pb, 1.86; Se, 0.44; Sr, 6.20; and Zn, 147.96. Data analysis showed that only Cr and Se concentrations
show a normal distribution, and no significant difference between male and female groups was found for any element except
Cr. Result also revealed that sufficient Se, Co, and Zn as well as lower or lack of exposure to Cr contribute positively to
the lifespan of centenarians. The results suggest that regulating in vivo contents of trace elements, especially Se, Co, and
Zn, is reasonable to intervene with geriatric diseases. |
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