A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide |
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| Authors: | Oh Sangtae Jeong In Howa Shin Woon Seob Lee Seokjoon |
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| Affiliation: | Department of Chemistry, Yonsei University, Wonju 220-710, South Korea. |
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| Abstract: | Coronarin A 1, epi-coronarin A 2 and some synthetic intermediates 14a and 14b synthesized from sclareolide exhibit good growth inhibition activities on HUVEC proliferation. In particular, coronarin A 1 and epi-coronarin A 2 effectively suppressed the growth factor induced tube formation of HUVEC at the concentration of 10 micro g/mL. |
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