Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker |
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| Authors: | Adriana Aguilar-Mahecha Christiane Cantin Maureen O'Connor-McCourt Andre Nantel Mark Basik |
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| Institution: | 1. Lady Davis Institute for Biomedical Research, Department of Oncology, Montréal, Québec, H3T 1E2, Canada
2. Biotechnology Research Institute, National Research Council of Canada, Montréal, Québec, H4P 2R2, Canada
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| Abstract: | Background Many putative disease blood biomarkers discovered in genomic and proteomic studies await validation in large clinically annotated
cohorts of patient samples. ELISA assays require large quantities of precious blood samples and are not high-throughput. The
reverse phase protein microarray platform has been developed for the high-throughput quantification of protein levels in small
amounts of clinical samples. |
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