| IL-3在造血干细胞增殖分化调控中的信号转导 |
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| 引用本文： | Guan T,Wang SL,Wang YP. IL-3在造血干细胞增殖分化调控中的信号转导[J]. 生理科学进展, 2006, 37(2): 117-120 |
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| 作者姓名： | Guan T Wang SL Wang YP |
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| 作者单位： | 重庆医科大学;重庆医科大学 |
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| 摘 要： | IL-3又称多克隆集落刺激因子（Multi-CSF）,是造血干细胞增殖分化的正性调节因子。它通过与靶细胞表面的受体结合传递生长、分化信号,调控造血干细胞生存、增殖及向各系血细胞分化、成熟。本文就IL-3在造血干细胞增殖分化调控中的有关信号转导作一综述。
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| 关 键 词： | IL-3 造血干细胞 信号转导 |
Signal transduction of IL-3 in regulating hematopoietic stem cell proliferation and differentiation |
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| Guan Tao,Wang Sha-Li,Wang Ya-Ping. Signal transduction of IL-3 in regulating hematopoietic stem cell proliferation and differentiation[J]. Progress in Physiological Sciences, 2006, 37(2): 117-120 |
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| Authors: | Guan Tao Wang Sha-Li Wang Ya-Ping |
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| Affiliation: | 1.Department of Physiology, Chongqing University of Medical Science; 2Chongqing Biochemistry and Molecule Pharmacology Key Laboratory, Chongqing 400016, China |
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| Abstract: | IL-3 is also called as multi-lineage colony stimulating factor, which can positively regulate proliferation and differentiation of hematopoietic stem cell. After binding to its receptor on target cell, IL- 3 can regulate hematopoietic stem cell to survive, proliferate, differentiate or to mature by transmiting growth, proliferation and differentiation signals. This paper is to summarize the signal transduction pathways of IL-3 in regulating hematopoietic stem cell proliferation and differentiation. |
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| Keywords: | IL-3 |
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