Synthesis of steroids containing the -keto acid side-chain |
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| Authors: | C Monder |
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| Affiliation: | Research Institute of the Hospital for Joint Diseases Mount Sinai School of Medicine 1919 Madison Avenue, New York, New YorkUSA |
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| Abstract: | ![]()
A general method for the chemical synthesis of steroidal 20-keto-21-oic acids is described. 21-Dehydrocorticosteroids, in the presence of catalytic amounts of cyanide ion, are oxidized by methylene blue or chromium trioxide at neutral pH to the corresponding keto acids. |
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