The iron-sulfur cluster assembly genes <Emphasis Type="Italic">iscS</Emphasis> and <Emphasis Type="Italic">iscU</Emphasis> of <Emphasis Type="Italic">Entamoeba histolytica</Emphasis> were acquired by horizontal gene transfer
(1) School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK
Abstract:
Background
Iron-sulfur (FeS) proteins are present in all living organisms and play important roles in electron transport and metalloenzyme
catalysis. The maturation of FeS proteins in eukaryotes is an essential function of mitochondria, but little is known about
this process in amitochondriate eukaryotes. Here we report on the identification and analysis of two genes encoding critical
FeS cluster (Isc) biosynthetic proteins from the amitochondriate human pathogen Entamoeba histolytica.