P80, the HinT interacting membrane protein,is a secreted antigen of <Emphasis Type="Italic">Mycoplasma hominis</Emphasis> |
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Authors: | Miriam?Hopfe Ricarda?Hoffmann Email author" target="_blank">Birgit?HenrichEmail author |
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Institution: | (1) Institute of Medical Microbiology and Center for Biological and Medical Research, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany |
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Abstract: | Background Mycoplasmas are cell wall-less bacteria which encode a minimal set of proteins. In Mycoplasma hominis, the genes encoding the surface-localized membrane complex P60/P80 are in an operon with a gene encoding a cytoplasmic, nucleotide-binding protein with a characteristic Histidine triad motif (HinT). HinT is found in both procaryotes and eukaryotes and known to hydrolyze adenosine nucleotides
in eukaryotes. Immuno-precipitation and BIACore analysis revealed an interaction between HinT and the P80 domain of the membrane
complex. As the membrane anchored P80 carries an N-terminal uncleaved signal peptide we have proposed that the N-terminus
extends into the cytoplasm and interacts with the cytosolic HinT. |
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