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The absolute configuration of prunioside A from Spiraea prunifolia and biological activities of related compounds |
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| Authors: | Oh Hyuncheol Shin Hyungsoo Oh Gi-Su Pae Hyun-Ock Chai Kyu-Yun Chung Hun-Taeg Lee Ho-Sub |
| Institution: | Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk 570-749, South Korea. |
| Abstract: | The stereochemistry of prunioside A isolated from Spiraea prunifolia was determined by chemical transformations and NMR spectral data analysis. The configurations at C-5 and C-6 were determined to be 5S and 6R by application of the modified Mosher's method, CD analysis, and 13C NMR spectroscopic data analysis of an acetonide derivative. Other compounds related to prunioside A have inhibitory effects on the synthesis of nitric oxide in LPS-stimulated macrophage-like RAW 264.7 cells. |
| Keywords: | Spiraea prunifolia Rosaceae Prunioside A Mosher's method Inhibitory effects on nitric oxide (NO) production |
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