Application of click chemistry towards an efficient synthesis of 1,2,3-1H-triazolyl glycohybrids as enzyme inhibitors |
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| Authors: | Anand Namarata Jaiswal Natasha Pandey Sarvesh Kumar Srivastava A K Tripathi Rama P |
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| Affiliation: | aMedicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), Lucknow 226 001, India;bBiochemistry Division, Central Drug Research Institute (CSIR), Lucknow 226 001, India |
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| Abstract: | An efficient synthesis of novel 1,2,3-1H-triazolyl glycohybrids with two or more than two sugar units or a chromenone moiety via copper-catalysed azide–alkyne cycloaddition (CuAAC), a 1,3-dipolar cycloaddition of glycosyl azides to 2,3-unsaturated alkynyl glycosides or propargyloxy coumarins is described. The synthesised glycohybrids were screened for their α-glucosidase, glycogen phosphorylase and glucose-6-phosphatase inhibitory activities. A few of the glycohybrids showed promising inhibitory activities against these enzymes. |
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| Keywords: | Click chemistry CuAAC Glycosyl triazoles α-Glucosidase Glucose-6-phosphatase Glycogen phosphorylase |
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