Hepatitis C virus-like particle morphogenesis |
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Authors: | Blanchard Emmanuelle Brand Denys Trassard Sylvie Goudeau Alain Roingeard Philippe |
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Institution: | Laboratoire de Virologie, E3M-EA3250, IFR 82, Faculté de Médecine et Centre Hospitalier Universitaire, Tours, France. |
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Abstract: | Although much is known about the hepatitis C virus (HCV) genome, first cloned in 1989, little is known about HCV structure and assembly due to the lack of an efficient in vitro culture system for HCV. Using a recombinant Semliki forest virus replicon expressing genes encoding HCV structural proteins, we observed for the first time the assembly of these proteins into HCV-like particles in mammalian cells. This system opens up new possibilities for the investigation of viral morphogenesis and virus-host cell interactions. |
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