Quantitative assessment of the association between TAP2 rs241447 polymorphism and cancer risk |
| |
| Authors: | Rongzeng Liu Yan Ma Xiafei Chen |
| |
| Institution: | 1. Department of Immunology, Medical College, Henan University of Science and Technology, Luoyang, China;2. Network Information Center, Children's Hospital of Kaifeng City, Kaifeng, China;3. Network Information Center, Henan University of Science and Technology, Luoyang, China |
| |
| Abstract: | The findings regarding the relation of transporter associated with antigen processing (TAP) to cancer risk have been inconsistent. The aim of this study was to comprehensively evaluate the association between TAP2 rs241447 polymorphism and cancer susceptibility. A meta-analysis of nine investigations with 2800 cases and 1620 controls was conducted to gain a better understanding of the effect of TAP2 rs241447 polymorphism on cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the correlation between TAP2 gene polymorphism and cancer susceptibility. The pooled results from TAP2 rs241447 polymorphism showed a decreased risk of cancer in two dominant genetic models (GG + AG vs AA: OR = 0.86, 95% CI, 0.75-0.99; AG vs AA: OR = 0.85, 95% CI, 0.73-0.99). From the subgroup analysis, decreased cancer susceptibility was found in Caucasians (GG + AG vs AA: OR = 0.82, 95% CI, 0.68-0.99), especially among the subgroup of cervical carcinoma (GG + AG vs AA: OR = 0.82, 95% CI, 0.69-0.96; AG vs AA: OR = 0.83, 95% CI, 0.70-0.99). Overall, the results suggest that TAP2 rs241447 polymorphism contributes to decreased cancer susceptibility. |
| |
| Keywords: | cancer meta-analysis polymorphism rs241447 TAP2 |
|
|
