LncRNA Erbb4-IR promotes esophageal squamous cell carcinoma (ESCC) by downregulating miR-145 |
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| Authors: | Yan Zhang Li Zhang Ruimin Wang Bin Wang Peiyan Hua Jindong Li |
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| Institution: | 1. Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China;2. Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, Jilin, China;3. Department of Operating Room, The Second Hospital of Jilin University, Changchun, Jilin, China |
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| Abstract: | Erbb4-IR is a recently identified lncRNA with pivotal functions in renal injury. The present study investigated the roles of Erbb4-IR in esophageal squamous cell carcinoma (ESCC). It was observed that Erbb4-IR was upregulated in tumor tissues of patients with ESCC. Plasma levels of Erbb4-IR in patients with ESCC were positively correlated with expression levels of Erbb4-IR in tumor tissues. MicroRNA-145 (miR-145) was downregulated in tumor tissues and inversely correlated with Erbb4-IR only in tumor tissues. Erbb4-IR overexpression led to downregulated miR-145, and increased rates of ECSS cell proliferation and decreased rates of ECSS cell apoptosis. Overexpression of miR-145 showed no significant effects on Erbb4-IR expression, but played an opposite role on cancer cell proliferation and apoptosis. In addition, miR-145 overexpression attenuated the effects of Erbb4-IR overexpression. Therefore, lncRNA Erbb4-IR may promote ESCC by downregulating miR-145. |
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| Keywords: | esophageal squamous cell carcinoma lncRNA Erbb4-IR miR-145 |
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