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S100 protein family and embryo implantation |
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| Authors: | Aydin Raei Sadigh Aynaz Mihanfar Amir Fattahi Zeinab Latifi Maryam Akbarzadeh Hamed Hajipour Zahra Bahrami-asl Aliyeh Ghasemzadeh Kobra Hamdi Hamid Reza Nejabati Mohammad Nouri |
| Institution: | 1. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;3. Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;5. Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands;6. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran;7. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| Abstract: | It is well known that embryo implantation is a critical process in which embryo should be able to reach and attach to endometrium. Until now, various types of factors are involved in the regulation of this process. S100 proteins are calcium-binding proteins, which have vital roles in embryo implantation and have been considered as possible candidate markers for endometrial receptivity. However, studies regarding mode of actions of these proteins are scarce and more mechanistic insights are needed to clarify exact roles of each one of the S100 protein family. Understanding of function of these proteins in different compartments, stages, and phases of endometrium, could pave the way for conducting studies regarding the therapeutic significance of these proteins in some disorders such as recurrent implantation failure. In this review, we outlined roles and possible underlying mechanisms of S100 protein family in embryo implantation. |
| Keywords: | embryo implantation recurrent implantation failure S100 proteins |