Cancer drug resistance: A fleet to conquer |
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| Authors: | Showket Hussain Ankita Singh Sheeraz Un Nazir Sonam Tulsyan Asiya Khan Ramesh Kumar Nasreena Bashir Pranay Tanwar Ravi Mehrotra |
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| Affiliation: | 1. Division of Cellular and Molecular Diagnostics, National Institute of Cancer Prevention and Research, Noida, India;2. Division of Preventive Oncology, National Institute of Cancer Prevention and Research, Noida, India;3. Department of Lab Oncology, AIIMS, New Delhi, India;4. Department of Biochemistry, Bundelkhand University, Jhansi, India;5. College of Applied Medicine, King Khalid University, Abha, Saudi Arabia |
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| Abstract: | Cancer is a disease that claims millions of lives each year across the world. Despite advancement in technologies and therapeutics for treating the disease, these modes are often found to turn ineffective during the course of treatment. The resistance against drugs in cancer patients stems from multiple factors, which constitute genetic heterogeneity like gene mutations, tumor microenvironment, exosomes, miRNAs, high rate of drug efflux from cells, and so on. This review attempts to collate all such known and reported factors that influence cancer drug resistance and may help researchers with information that might be useful in developing better therapeutics in near future to enable better management of several cancers across the world. |
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| Keywords: | alternate signaling pathway cancer drug resistance exosomes miRNAs tumor microenvironment |
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