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Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural-like cells |
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| Authors: | Elaheh Esmaeili Masoud Soleimani Mohammad Adel Ghiass Shadie Hatamie Saeed Vakilian Mahsa Soufi Zomorrod Negar Sadeghzadeh Manouchehr Vossoughi Simzar Hosseinzadeh |
| Affiliation: | 1. Stem Cell Technology Research Center, Tehran, Iran;2. Department of Hematology and Cell Therapy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;3. Department of Tissue Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Ghiass, Hatamie, Vakilian contributed equally to this work.;4. Stem Cell Technology Research Center, Tehran, Iran Ghiass, Hatamie, Vakilian contributed equally to this work.;5. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran;6. Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
| Abstract: | While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive filler, CoFe2O 4 nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through a hydrothermal process. After that, the piezoelectric PVDF polymer, which contained the magnetic nanoparticles, underwent the electrospun process to form ME nanofibers, the ME property of which has the potential to be used in areas such as tissue engineering, biosensors, and actuators. |
| Keywords: | electrospinning magnetoelectric mesenchymal stem cells neural differentiation scaffold |