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The immunomodulatory role of probiotics in allergy therapy |
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| Authors: | Jafar Hajavi Seyed-Alireza Esmaeili Abdol-Reza Varasteh Hossein Vazini Hadi Atabati Fatemeh Mardani Amir A. Momtazi-Borojeni Maryam Hashemi Mojtaba Sankian Amirhossein Sahebkar |
| Affiliation: | 1. Department of Basic Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran Jafar Hajavi and Seyed-Alireza Esmaeili contributed equally to this study.;2. Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Jafar Hajavi and Seyed-Alireza Esmaeili contributed equally to this study.;3. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;4. Nursing Department, Basic Sciences Faculty, Hamedan Branch, Islamic Azad University, Hamedan, Iran;5. Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran;6. Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran;7. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Biotechnology, Nanotechnology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;8. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;9. Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | The increased incidence of allergic disorders may be the result of a relative fall in microbial induction in the intestinal immune system during infancy and early childhood. Probiotics have recently been proposed as viable microorganisms for the prevention and treatment of specific allergic diseases. Different mechanisms have been considered for this probiotic property, such as generation of cytokines from activated pro-T-helper type 1 after bacterial contact. However, the effects of its immunomodulatory potential require validation for clinical applications. This review will focus on the currently available data on the benefits of probiotics in allergy disease. |
| Keywords: | allergy immune system microbiota probiotics |