Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistance |
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| Authors: | Aynaz Mihanfar Javad Aghazadeh Attari Iraj Mohebbi Maryam Majidinia Mojtaba Kaviani Mehdi Yousefi Bahman Yousefi |
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| Institution: | 1. Faculty of Medicine, Department of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Neurosurgery, Urmia University of Medical Sciences, Urmia, Iran;3. Department of Occupational Health, Urmia University of Medical Sciences, Urmia, Iran;4. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran;5. School of Nutrition and Dietetics, Acadia University, Wolfville, Nova Scotia, Canada;6. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;7. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
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| Abstract: | The cancer stem cell (CSC) model encompasses an advantageous paradigm that in recent decades provides a better elucidation for many important biological aspects of cancer initiation, progression, metastasis, and, more important, development of multidrug resistance (MDR). Such several other hematological malignancies and solid tumors and the identification and isolation of ovarian cancer stem cells (OV-CSCs) show that ovarian cancer also follows this hierarchical model. Gaining a better insight into CSC-mediated resistance holds promise for improving current ovarian cancer therapies and prolonging the survival of recurrent ovarian cancer patients in the future. Therefore, in this review, we will discuss some important mechanisms by which CSCs can escape chemotherapy, and then review the recent and growing body of evidence that supports the contribution of CSCs to MDR in ovarian cancer. |
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| Keywords: | cancer stem cells CSC markers multidrug resistance ovarian cancer self-renewal tumor-initiating cells |
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